Analysis of secundary lesions in Sprague-Dawley rats subject to a mammary carcinogenic model by chemical inducing

Abstract

Breast cancer still persists as the malignancy that most kill woman all over the world. Several carcinogenic models in female rats are used so that this disease can be more studied. Thus, this paper aims to, by the 7, 12- dimethylbenz (a) nthracene inducing, investigate the secondary lesions arising from the treatment with this carcinogenic model. As an experimental method, 10 rats, 40 days old, were used. They were equally divided into control group and DMBA treated group and, after tumor development, were euthanized and organ harvesting. As results, we obtained and average of 4 tumors per animal in the DMBA group, while in the control group there were no tumor development. It was observed macroscopic changes in the DMBA group, such as increased spleen size and formation of kidney stones in one of the rats. Microscopically, in the bladder of one of the rats of DMBA group, it was noted the development of a neoplasia. In one rat, it was also observed benign skin lesions attached to one of the breast tumors. It is then concluded, by these results, that the acute treatment of DMBA had 80% success in the development of mammary tumors and that secondary injuries, such as cancer in the bladder and changes in the spleen, had low relevancy score.