UMA REVISÃO DE LITERATURA

a literature review

Abstract

Invasive aspergillosis (IA) remains a fatal and difficult to treat infection in immunocompromised patients. The standard treatment is insufficient for these patients, often impairing their quality of life due to adverse effects, in addition to the extensive treatment time. Through a literature review using the base dates PubMed, Lilacs and MedLine, accepting only articles published from 2010 to 2020, and only those in Portuguese or English, with 23 articles selected, of which 7 were included in this review. There was a prevalence of treatments with voriconazole, used in six of the seven studies reviewed, in addition to being part of the standard Brazilian treatment. Studies regarding the treatment of IA are heterogeneous, making it difficult to compare effectively between publications. Well-designed controlled, randomized and multicenter clinical trials are needed to adequately address the issue of the usefulness of the approaches used in Brazil. In addition, combined therapies come in many different forms, requiring cumulative evidence to support the use of combined antifungal therapy in AI, as they are still conflicting and of moderate strength.