Benefits of probiotics in chronic kidney disease

Abstract

Chronic kidney disease (CKD) is characterized by the condition in which the kidneys lose the ability to perform their basic activities, as well as partially losing their renal function, in a progressive and irreversible manner. Studies in rodents have indicated that individuals with chronic kidney disease exhibit impaired functions of the intestinal epithelium, suggesting microbiota disorders. Through a literature review, the aim was to evaluate the presence of dysbiosis and the effects of probiotic use in chronic kidney patients, based on scientific articles from electronic databases, spanning from 2010 to 2020, prioritizing the most recent ones. It was observed that dysbiosis is directly related to kidney disease, as the conditions during the treatment of the pathology alter the microbiota, leading to the accumulation of uremic toxins. In studies involving probiotics, a 10% reduction in the individual's serum urea concentration was analyzed. Furthermore, this study highlighted the importance of probiotic use in renal patient treatments; however, based on the analyzed studies, further investigation into the topic is warranted, as the results obtaine lacked a sufficient sample size, precise dosage, and treatment duration for a solid conclusion.